Penyembuhan luka sayatan kulit menggunakan topikal balsamum peruvianum pascaoperasi infark miokardium pada babi domestik (Sus scrofa domestica)

Agung Febryanto; Dwi Utari Rahmiati; Ietje Wientarsih; Fitria Senja Murtiningrum; Bintang Nurul Iman; Deni Noviana; Gunanti Gunanti

doi:10.29244/currbiomed.1.1.25-32

Agung Febryanto Program Studi Sarjana Kedokteran Hewan, Sekolah Kedokteran Hewan dan Biomedis, IPB University, Bogor
Dwi Utari Rahmiati Divisi Bedah dan Radiologi, Sekolah Kedokteran Hewan dan Biomedis, IPB University, Bogor
Ietje Wientarsih Sub-divisi Farmasi, Sekolah Kedokteran Hewan dan Biomedis, IPB University, Bogor
Fitria Senja Murtiningrum Program Studi Magister Ilmu Biomedis Hewan, Sekolah Pascasarjana, IPB University, Bogor
Bintang Nurul Iman Program Studi Magister Ilmu Biomedis Hewan, Sekolah Pascasarjana, IPB University, Bogor
Deni Noviana Divisi Bedah dan Radiologi, Sekolah Kedokteran Hewan dan Biomedis, IPB University, Bogor
Gunanti Gunanti Divisi Bedah dan Radiologi, Sekolah Kedokteran Hewan dan Biomedis, IPB University, Bogor

DOI: https://doi.org/10.29244/currbiomed.1.1.25-32

Keywords: balsamum peruvianum, myocardial infarction surgery, skin, swine, wound healing

Abstract

Background: Swine are ideal animal models used for human health and disease research in humans because they have similar anatomy and physiology, one of which is regarding wound healing. Objective: This study aims to determine the effectiveness of balsamum peruvianum on wound healing after myocardial infarction surgery in domestic pigs (Sus scrofa domestica). Methods: The study used five pigs aged 4–5 months, three male and two female. The incision was made using electrocautery in the lateral part of the third and fourth thoracic intercostal spaces, lengthwise from dorsal to ventral. The wound was sutured using Monosyn® 4.0 thread with a subcuticular/intradermal suture pattern. The wound was then given 10% iodine and 10% balsamum peruvianum over the entire surface of the wound twice a day. Recovery was observed on 1st, 4th, 7th, 11th, and 14^th days and was scored (grade: 1–4) on macroscopic examination in each pig until day 18th. Results: The observations showed a significant difference in recovery scores on the 11th and 18th days compared to the first day. Conclusion: Topical balsamum peruvianum can be used and is effective for wound healing of skin incisions after myocardial infarction surgery in swine.

Wound healing of skin incision using topical balsamum peruvianum after myocardium infarction surgery in domestic swine (Sus scrofa domestica)

Abstract