Anthiypercholesterolaemic Activity of Zincophyllin

. Alsuhendra, D Muchtadi, D Sastradipradja, T Wresdiyati


Pheophytin was obtained from chlorophyll that was extracted from fresh cassava leaves by use of ethanol. One hundred to 200 ppm of zinc was added to pheophytin to produce a complex of zinc-pheophytin (“zincophyllin”). The antihypercholesterolaemic effect of “zincophyllin” was studied in 20 male New Zealand White rabbits fed on a low-cholesterol (0.1%) diet for 12 weeks. Five animals were given 33.4 mg/d (doses I), 5 animals received 100.2 mg/d (doses II) of “zincophyllin”, 5 animals received standard diet as negative controls, and the remaining 5 animals served as cholesterol-fed controls (positive controls). Animal receiving dose Ii had significantly lower serum total and LDL-cholesterol concentrations. Positive control group and doses I group had significantly higher serum total cholesterol. Cholesterol concentration of group II slightly increased for 4 weeks, but decreased to normal until 12 weeks. Triglyceride concentration of all rabbits groups were in normal level, but LDL-cholesterol concentration of positive control group and doses I group were higher than others. It was suggested that the antihypercholesterolaemic effect of “zincophyllin” may benefit rabbits by inhibiting the increase of serum cholesterol concentration.

Key words: Chlorophyll, pheophytin, “zincophyllin”, hypercholesterolaemic


. Alsuhendra (Primary Contact)
D Muchtadi
D Sastradipradja
T Wresdiyati
Alsuhendra., MuchtadiD., SastradipradjaD., & WresdiyatiT. (2010). Anthiypercholesterolaemic Activity of Zincophyllin. Jurnal Teknologi Dan Industri Pangan, 14(2), 129. Retrieved from
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