Gambaran Makroskopis Persembuhan Luka Mukosa Buccal Tikus Putih (Rattus norvegicus) Pascapemberian Policresulen

  • Tri Isyani Tunggadewi RSHP FKH IPB
  • Tony Wahyudi PT Pharos Indonesia
  • Aisyah Alviatus Shofwan Program Sarjana, Fakultas Kedokteran Hewan, Institut Pertanian Bogor
  • Anggri Azhari Khoerunnisa Program Sarjana, Fakultas Kedokteran Hewan, Institut Pertanian Bogor
  • Huda Salahudin Darusman Divisi Farmakologi dan Toksikologi Departemen Anatomi Fisiologi dan Farmakologi Fakultas Kedokteran Hewan, Institut Pertanian Bogor

Abstract

This study aimed to investigate the effect of policresulen treatment with various concentrations on the wound healing in buccal mucosa of white rats (Rattus norvegicus) through macroscopically observation. The number of 54 rats were divided into six treatment groups policresulen with concentration of 36%, 10%, 5%, 1%, 0.3% and one control group. The buccal mucosal injury was made with a 0.5 cm biopsy punch. The treatment of mucosal injury was conducted by dropped policresulen on the 2nd day until the 5th day after the injury. Macroscopic observation under a stereo micro-scope was conducted on the wound diameter, redness, swelling, and necrose. The results showed that wound healing was influenced significantly with concentration of the policresulen. The best healing was shown on lowest concentration marked which has lowest size of the wound diameter (0.50 ± 0.00 cm), the lowest tissue redness (0.00 ± 0.00), lowest final swelling at a concentration of 0.3%. Clinical evaluation of wound tissue necrose parameters which were seen to be most severe at 10% policresulen administration followed by 36% concentration and the least necrose shown on policresulen administration 0.3%. Therefore, based on macroscopic images with parameters of wound diameter, redness, swelling, and necrose suggested that policresulen used for wound healing process are at a concentration of 0.3%.

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Author Biography

Tri Isyani Tunggadewi, RSHP FKH IPB

Laboratorium Riset dan Diagnostik

Rumah Sakit Hewan Pendidikan 

Fakultas Kedokteran Hewan

Institut Pertanian Bogor

References

Diegelmann RF, Evans MC. 2004. Wound healing: an overview of acute, fibrotic, and delayed healing. Frontiers in Bioscience. 9 (1): 283-289.

Freire MO, Van Dyke TE. 2013. Natural resolution of inflammation. Periodontology 2000. 63(1): 149-164.

Gupta PJ. 2007. Suppositories in anal disordes: a review. European Review for Medical and Pharmacological Sciences. 11(3): 165-170.

Hullah EA, Hegarty AM. 2014. Oral ulceration: aetiology, diagnosis, and treatment. Dental Nursing. 10(9): 507-519.

Mawarsari T. 2015. Uji aktivitas penyembuhan luka bakar ekstrak etanol umbi talas jepang (Colocasia esculenta (L.) Schott var. antiquorum) pada tikus putih (Rattus norvegicus) jantan galur Sprague Dawley [skripsi]. Jakarta (ID): UIN Syarif Hidayatullah Jakarta: Fakultas Kedokteran dan Ilmu Kesehatan.

Wardhany II, Wimardhani YS, Soegyanto AI. 2016. Oral mucosal burn caused by topical application of 36% policresulen solution – a case series. Journal of International Dental and Medical Research. 9(Special Issue): 387- 391.

Published
2021-04-02
How to Cite
TunggadewiT. I., WahyudiT., ShofwanA. A., KhoerunnisaA. A., & DarusmanH. S. (2021). Gambaran Makroskopis Persembuhan Luka Mukosa Buccal Tikus Putih (Rattus norvegicus) Pascapemberian Policresulen. ARSHI Veterinary Letters, 4(3), 57-58. https://doi.org/10.29244/avl.4.3.57-58