Quantitative Trait Loci (QTL) Analysis for Production Traits of Birth Weight and Weight 360 days in Backcross Sheep

  • ENDANG TRI MARGAWATI
  • HERMAN WILLEM RAADSMA
  • HARIMURTI MARTOJO
  • SUBANDRIYO SUBANDRIYO
  • MULADNO MULADNO
DOI: https://doi.org/10.4308/hjb.13.1.31

Abstract

Four half-sib families (n = 382) consisting predominantly of ITT x Merino x Merino backcross progeny, including some F2 progeny were used to analyze QTL for two production traits (Birth weight = BW1 and Body weight at 360 days = BW360). The study exploited differences in weight performance between the Merino and ITT sheep. A total of 141 informative microsatellite markers were used in a genome-wide scan covering the 26 autosomal sheep chromosomes. QTL analysis was conducted online using QTL Express. This study reports the effect of QTL for birth weight on Chromosomes 5 (p < 0.05) at 112cM (0cM-128cM). Location of candidate genes for birth weight was predicted at the region of flanking markers MCM527-BMS1247. A QTL for BW360 days existed on Chromosome 18 (p < 0.01) at 104cM (25.0-125cM). Location of candidate genes related to production traits for body weight 360 days was predicted at the segment of flanking markers of CSSM018-TMR1. Only the QTL on Chromosome 18 retained significance (p < 0.01) under experiment-wide significance testing. This QTL region is being examined for candidate genes by investigating to the homologous human chromosomal segments.

Key words: Quantitative trait loci, production traits, birth weight, weigh 360, backcross sheep

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MARGAWATIE. T., RAADSMAH. W., MARTOJOH., SUBANDRIYOS., & MULADNOM. (1). Quantitative Trait Loci (QTL) Analysis for Production Traits of Birth Weight and Weight 360 days in Backcross Sheep. HAYATI Journal of Biosciences, 13(1), 31. https://doi.org/10.4308/hjb.13.1.31
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Vol. 13 No. 1 (2006): March 2006
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Articles

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