@article{Tejasari_Zakaria_Sajuthi_2013, title={AKTIVITAS STIMULASI KOMPONEN BIOAKTIF RIMPANG JAHE (Zingiber officinale Roscoe) PADA SEL LIMFOSIT B MANUSIA SECARA IN VITRO [Effects of Bioactive Compounds of Ginger (Zingiber officinale Roscoe) Root on B Cell Lymphocyte Function using In Vitro System}, volume={13}, url={https://jurnal.ipb.ac.id/index.php/jtip/article/view/7024}, abstractNote={<em><span style="font-size: 9pt;" lang="en-gb" xml:lang="en-gb">The effect of two fractions of oleoresin compounds from ginger root on lymphocyte function were studied by observing B cell proliferations, which were<span>  </span>measured by the incorporation of 3H-thymidine during cell incubation. The doses of oleoresin compounds and its two fractions tested were 50,100, 150, and 200 </span></em><em><span style="font-size: 9pt; font-family: Symbol;" lang="en-gb" xml:lang="en-gb"><span>m</span></span></em><em><span style="font-size: 9pt;" lang="en-gb" xml:lang="en-gb">g per ml. Lymphocyte from human peripheral blood were isolated using ficoll density gradient technique, and cultured<span>  </span>in the presence of the compounds in RPMI-1640 medium for 4 days, with or without the addition of 3 mM paraquat as the oxidizing agent.<span>  </span></span></em><p class="MsoNormal" style="text-align: justify; text-indent: 27pt;"><em><span style="font-size: 9pt;" lang="en-gb" xml:lang="en-gb">The results showed that the effects of oleoresin and its two fractions depended on its doses. Oleoresin and its two fractions increased B cell proliferation with<span>  </span>the highest activity of 456 percent at low dose of 50 </span></em><em><span style="font-size: 9pt; font-family: Symbol;" lang="en-gb" xml:lang="en-gb"><span>m</span></span></em><em><span style="font-size: 9pt;" lang="en-gb" xml:lang="en-gb">g per ml. These result showed a positive effect of oleoresin compound and its two fractions on B cell functions<span>  </span>at low doses. It indicated that bioactive compounds of ginger root at low<span>  </span>concentration have<span>  </span>positive effects on humoral immune response and this supports the traditional belief that ginger increases body resistance to common cold. </span></em></p&gt;}, number={1}, journal={Jurnal Teknologi dan Industri Pangan}, author={Tejasari. and ZakariaFransiska R and Sajuthi, Dondin}, year={2013}, month={Sep.}, pages={47} }