@article{Hardoko_Febriani_Siratantri_2015, place={Bogor, ID}, title={Invitro Antidiabetic Activities of Agar, Agarosa, and Agaropectin from Gracilaria gigas Seaweed}, volume={18}, url={https://jurnal.ipb.ac.id/index.php/jphpi/article/view/10608}, DOI={10.17844/jphpi.v18i2.10608}, abstractNote={<p>Some types of seaweed are reported to have antidiabet activity in vivo or in vitro,<br />but the activity antidiabet fractions of polysaccharides from seaweed has not been widely<br />reported. Gracilaria gigas is one type of red seaweed that can produce agar and it has two<br />factions, namely agarose and agaropectin. The aim of this study was to obtain an agar<br />extract, agarose fraction, agaropektin fraction of Gracilaria gigas and to determine the<br />α-glucosidase inhibitory activity of extracts and the fractions. Extraction of agar that used<br />an ethanol solution, and to fractionate agarose and agaropektin used dimetilsulfoxide<br />solution. The results showed that the fraction of the agarose having lower sulfate content<br />(0.28%) compared with agar (5.91%) and agaropektin (6.07%). Types of samples (agar,<br />agarose, and agaropektin) and sample doses significantly in inhibiting α-glucosidase<br />enzyme activity. Agarose fraction has IC50 value against α-glucosidase lowest (96.86 ± 4.61<br />ppm), followed by the extract agar (116.63 ± 5.61 ppm), then the fraction agaropektin<br />(158.34 ± 1.77 ppm).<br />Keywords: α-glucosidase, extract, fraction, Gracilaria gigas, IC50</p&gt;}, number={2}, journal={Jurnal Pengolahan Hasil Perikanan Indonesia}, author={HardokoH. and Febriani, Agnes and Siratantri, Titri}, year={2015}, month={Nov.} }