EFEK PEMBERIAN SUSU SAPI BUBUK TERHADAP KADAR SERUM HDL (HIGH DENSITY LIPOPROTEIN) PADA TIKUS PUTIH (Rattus norvegicus) GALUR WISTAR MODEL DIABETES MELITUS TIPE 2

Zakia Umami, Nurdiana Nurdiana, Fajar Ari Nugroho

Abstract

ABSTRACT

The purpose of this study was to determine the cow’s milk powder to increased serum levels of High Density Lipoprotein (HDL) of white male rat model with diabetes mellitus type 2. The design of this study was a post-test control group study conducted in 30 male rats which randomly divided into five groups. Negative control group was the group of rats which fed normally, the positive control group was induced by streptozotocin (STZ) without given cow’s milk, group P1, P2, P3 were given a normal diet and cow’s milk 0.9; 1.8, and 2.7 g orally every day. The results of this study were the levels of HDL in K(-)=44.22 mg/dl, K(+)=47.45 mg/dl, P1=56.56 mg/dl, P2=51.82 mg/dl, and P3=59.45 mg/dl. The conclusion was the milk powder was not significantly increase levels of HDL (p>0.05). More longer intervention was suggested for further research to get more significant of HDL level on type 2 diabetes mellitus.

Keywords: HDL serum level, high fat diet, milk powder, streptozotocin

ABSTRAK

Tujuan penelitian ini adalah menganalisis pengaruh pemberian susu sapi bubuk terhadap peningkatan kadar serum High Density Lipoprotein (HDL) tikus putih (Rattus norvegicus) berjenis kelamin jantan model diabetes melitus (DM) tipe 2. Penelitian ini menggunakan desain penelitian post test control group dengan 30 ekor tikus dibagi secara acak menjadi lima kelompok. Kelompok K(-) adalah tikus yang diberi pakan normal, kelompok K(+) diinduksi dengan streptozotocin (STZ) tanpa diberi susu, kelompok P1 sampai P3 diberi diet normal dan susu 0,9; 1,8, dan 2,7 g secara oral setiap hari. Hasil penelitian menunjukkan kadar HDL pada K(-)=44,22 mg/dl, K(+)=47,45 mg/dl, P1=56,56 mg/dl, P2=51,82 mg/dl, dan P3=59,45 mg/dl. Susu sapi bubuk mampu meningkatkan kadar HDL tikus model DM tipe 2 akan tetapi tidak signifikan (p>0,05). Perlu dilakukan penelitian lebih lanjut dengan waktu lama penelitian yang berbeda sehingga bisa berdampak yang lebih signifikan untuk kadar HDL pada DM tipe 2.

Kata kunci: diet tinggi lemak, kadar HDL serum, streptozotocin, susu sapi bubuk

Authors

Zakia Umami
zakia.umami@gmail.com (Primary Contact)
Nurdiana Nurdiana
Fajar Ari Nugroho
UmamiZ., NurdianaN., & NugrohoF. A. (2015). EFEK PEMBERIAN SUSU SAPI BUBUK TERHADAP KADAR SERUM HDL (HIGH DENSITY LIPOPROTEIN) PADA TIKUS PUTIH (Rattus norvegicus) GALUR WISTAR MODEL DIABETES MELITUS TIPE 2. Jurnal Gizi Dan Pangan, 10(1). https://doi.org/10.25182/jgp.2015.10.1.%p
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