@article{Kamath_Dwarakanath_Chaudhary_Janakiraman_2016, title={Optimization of Culture Conditions for Maximal Lovastatin Production by Aspergillus terreus (KM017963) under Solid State Fermentation}, volume={22}, url={https://jurnal.ipb.ac.id/index.php/hayati/article/view/12102}, DOI={10.4308/hjb.22.4.174}, abstractNote={<span>Effects of various culture conditions on lovastatin production were investigated in </span><em>Aspergillus terreus</em><span> (KM017963) grown under solid state fermentation with wheat bran. Lovastatin production was influenced by various physical factors such as pH, temperature, and nutritional factors such as carbon, nitrogen, metal ions/salts etc. Our study established that an initial pH of 6.0, growth temperature of 28 °C–30 °C, inoculum size of 10</span><sup>8</sup><span> spores/mL as the optimal physiological culture conditions for maximal production of lovastatin by </span><em>A. terreus</em><span> (KM017963). The carbon sources, glucose or dextrin when supplemented at 3% (w/w) enhanced lovastatin production by five fold when supplemented as individual component in wheat bran. Addition of metal salts such as CuSO</span><sub>4</sub><span> (8%), FeSO</span><sub>4</sub><span> (8%), CaCl</span><sub>2</sub><span> (10%), NaCl (6%) and MgSO</span><sub>4</sub><span> (6%) enhanced the production by five fold. Supplementation with nitrogen sources, amino acids, hydrocarbons, surfactants and amino acids did not have any profound effect on lovastatin production.</span&gt;}, number={4}, journal={HAYATI Journal of Biosciences}, author={KamathPraveen Vadakke and DwarakanathBhargavi Santebennur and Chaudhary, Avinash and Janakiraman, Savitha}, year={2016}, month={May}, pages={174} }