Propolis Components and Biological Activities from Stingless Bees Collected on South Sulawesi, Indonesia

Ryo  Miyata; Muhamad  Sahlan; Yoshinobu  Ishikawa; Hiroshi  Hashimoto; Sari  Honda; Shigenori  Kumazawa

doi:10.4308/hjb.27.1.82

Propolis Components and Biological Activities from Stingless Bees Collected on South Sulawesi, Indonesia

Ryo Miyata Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka
Muhamad Sahlan Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok
Yoshinobu Ishikawa Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka
Hiroshi Hashimoto Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka
Sari Honda Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka
Shigenori Kumazawa Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka

DOI: https://doi.org/10.4308/hjb.27.1.82

Abstract

Three new compounds, namely sulabiroins A (1) and B (2), and 2',3'-dihydro-3'-hydroxypapuanic acid (3), were isolated from the propolis of stingless bees (Tetragonula aff. biroi) collected on South Sulawesi, Indonesia. In addition, ten known compounds, (–)-papuanic acid (4), (–)-isocalolongic acid (5), isopapuanic acid (6), isocalopolyanic acid (7), glyasperin A (8), broussoflavonol F (9), (2S)-5,7-dihydroxy-4'-methoxy-8-prenylflavanone (10), isorhamnetin (11), (1'S)-2-trans,4-trans-abscisic acid (12), and (1'S)-2-cis,4-trans-abscisic acid (13) were identified. The structures of the new and known compounds were determined by spectroscopic analysis. The absolute configurations of sulabiroins A (1) and B (2) were determined by X-ray crystallography analysis and ECD calculation, respectively. The propolis from stingless bee (Tetragonula aff. biroi) collected on South Sulawesi contained compounds not present in propolis from other regions. Sulabiroin A (1) and isorhamnetin (11) were examined for xanthine oxidase (XO) inhibitory activity as one of biological activities; isorhamnetin (11) exhibited potent XO inhibitory activity, with an IC₅₀ value of 3.9 µm.

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Published

2020-01-01

How to Cite

MiyataR., SahlanM., IshikawaY., HashimotoH., HondaS., & KumazawaS. (2020). Propolis Components and Biological Activities from Stingless Bees Collected on South Sulawesi, Indonesia. HAYATI Journal of Biosciences, 27(1), 82. https://doi.org/10.4308/hjb.27.1.82

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Vol. 27 No. 1 (2020): January 2020

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