Propolis Components and Biological Activities from Stingless Bees Collected on South Sulawesi, Indonesia

  • Ryo Miyata Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka
  • Muhamad Sahlan Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok
  • Yoshinobu Ishikawa Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka
  • Hiroshi Hashimoto Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka
  • Sari Honda Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka
  • Shigenori Kumazawa Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka

Abstract

Three new compounds, namely sulabiroins A (1) and B (2), and 2',3'-dihydro-3'-hydroxypapuanic acid (3), were isolated from the propolis of stingless bees (Tetragonula aff. biroi) collected on South Sulawesi, Indonesia. In addition, ten known compounds, (–)-papuanic acid (4), (–)-isocalolongic acid (5), isopapuanic acid (6), isocalopolyanic acid (7), glyasperin A (8), broussoflavonol F (9), (2S)-5,7-dihydroxy-4'-methoxy-8-prenylflavanone (10), isorhamnetin (11), (1'S)-2-trans,4-trans-abscisic acid (12), and (1'S)-2-cis,4-trans-abscisic acid (13) were identified. The structures of the new and known compounds were determined by spectroscopic analysis. The absolute configurations of sulabiroins A (1) and B (2) were determined by X-ray crystallography analysis and ECD calculation, respectively. The propolis from stingless bee (Tetragonula aff. biroi) collected on South Sulawesi contained compounds not present in propolis from other regions. Sulabiroin A (1) and isorhamnetin (11) were examined for xanthine oxidase (XO) inhibitory activity as one of biological activities; isorhamnetin (11) exhibited potent XO inhibitory activity, with an IC50 value of 3.9 µm.

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Published
2020-01-01
How to Cite
Miyata, R., Sahlan, M., Ishikawa, Y., Hashimoto, H., Honda, S., & Kumazawa, S. (2020). Propolis Components and Biological Activities from Stingless Bees Collected on South Sulawesi, Indonesia. HAYATI Journal of Biosciences, 27(1), 82. https://doi.org/10.4308/hjb.27.1.82